Fumaric acid, also known as trans-butanedioic acid, is an
unsaturated dicarbonic acid, the trans iosmer of malic acid and is an
intermediate in the citric acid cycle (Krebs cycle), the center for
energy production in each cell. It is the by-product of the cycle and
therefore present in every cell. When sun is exposed to healthy
individuals' skin, the ultra violet rays form fumaric acid. In
individuals with psoriasis, fumaric acid is not formed as quickly as
in healthy individuals and must require longer exposure to sunlight.
A lack of fumaric acid leads to the accumulation of half-products,
thought to be the cause of psoriatic lesions. Psoriasis is possibly a
fumaric acid metabolism defect.
- Intermediate in the Krebs cycle
- Prevents accumulation of half-products in the skin
- Take 1 capsule daily at the end of each meal on a full stomach
for 2 weeks
Then, 2 capsules daily at the end of each meal on a full stomach
for 2 weeks
Finally, 3 capsules daily at the end of each meal on a full
stomach for 3 weeks
- 15 - 30 minutes after dosage, the skin, shoulders, neck
regions up to the ear lobes should grow warm and tingle for
approximately 30 minutes, which indicates the fumaric acid
metabolic process has started. If this does not occur, the dosage
should be increased.
- Do NOT take these medications while taking fumaric acid:
Beta blockers, i.e. propranolol
Adverse Reactions and Toxicity:
- Usually well tolerated
Too much fumaric acid can result in heat wave and a drop in blood
Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).