Fumaric Acid


Fumaric acid, also known as trans-butanedioic acid, is an unsaturated dicarbonic acid, the trans iosmer of malic acid and is an intermediate in the citric acid cycle (Krebs cycle), the center for energy production in each cell. It is the by-product of the cycle and therefore present in every cell. When sun is exposed to healthy individuals' skin, the ultra violet rays form fumaric acid. In individuals with psoriasis, fumaric acid is not formed as quickly as in healthy individuals and must require longer exposure to sunlight. A lack of fumaric acid leads to the accumulation of half-products, thought to be the cause of psoriatic lesions. Psoriasis is possibly a fumaric acid metabolism defect.

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Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).