Glucosamine Sulfate

Description:

Biochemically, D-glucosamine leads to N-acetyl-D-glucosamine (NAG) which leads to Glycosaminoglycans (GAG) which leads to Proteoglycans (PG) of articular surfaces, synovial fluid, cartilage, ligaments, bones, tendons, sclera, nails, skin, blood vessels and heart valves and mucous secretions of the digestive, urinary and respiratory tracts. Glucosamine is an aminomonosaccharide produced by combination of glucose with glutamine by the enzyme, glucosamine synthetase. It is also the primary substrate for the biosynthesis of hyaluronic acid and chondroitin sulfate. Glucosamine's action is enhanced by the presence of sulfate, an essential component of proteoglycans. Glucosamine sulfate (GS) is thus a component of glycopoteins and glycosaminoglycans.

Physiologic Functions:

Inhibits cartilage lesions from developing in animal models of arthrosis
Integrates with metabolic pool of endogenous glycosaminoglycans
Provides sulfate ions for synthesis of chondroitin sulfate and keratan sulfate
Stimulates the synthesis of proteoglycans and glycosaminoglycans

Indications:

Contraindications:

None

Toxicity:

None