Biochemically, D-glucosamine leads to N-acetyl-D-glucosamine (NAG) which leads to Glycosaminoglycans (GAG) which leads to Proteoglycans (PG) of articular surfaces, synovial fluid, cartilage, ligaments, bones, tendons, sclera, nails, skin, blood vessels and heart valves and mucous secretions of the digestive, urinary and respiratory tracts. Glucosamine is an aminomonosaccharide produced by combination of glucose with glutamine by the enzyme, glucosamine synthetase. It is also the primary substrate for the biosynthesis of hyaluronic acid and chondroitin sulfate. Glucosamine's action is enhanced by the presence of sulfate, an essential component of proteoglycans. Glucosamine sulfate (GS) is thus a component of glycopoteins and glycosaminoglycans.
Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).