References for Hepatitis - Natural Medical Protocols

Below are supplemental abstracts and references of research that support the conclusions on the treatment for Hepatitis

Vegetable Consumption

Yu MW, et al. "Vegetable consumption, serum retinol level, and risk of hepatocellular carcinoma." Cancer Res. March1995;55:1301-1305.

Tumeric

Kiso Y, et al. "Antihepatotoxic principals of Curcuma longa rhizomes." J Medicinal Plant Res. 1983;49:185-187.

Vitamin and Mineral References

Vitamin B12 and Folate

Bosy-Westphal A, et al. "Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation." Am J CIN Nutr. 2003;77:1269-1277.

Vitamin C

Harrison SA, et al. "Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis." Am J Gastroenterol. 2003;98(11):2485-2490.

Mehta K, et al. "Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants." Nutr Rev. September,2002;60(9):289-293.

Beck MA, Levander OA, "Dietary oxidative stress and the potentiation of viral infection." Ann Rev Nutr. 1998;18:93-116.

Klenner FR. "Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology." J Orthomol Med. 1998;13(4):198-210.

Hemila H. "Vitamin C and infectious diseases." Vitamin C: The State of the Art in Disease Prevention Sixty Years After the Nobel Prize 1998:73-85.

Yamamoto Y, et al. "Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants." Biochem Biophys Res Comm. 1998;247:166-170.

Peterhans E. "Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation." J Nutr. 1997;127:962S-965S.

Loft S, Poulsen HE. "Cancer risk and oxidative DNA damage in man." J Molec Med. 1996;74:297-312.

Vitamin E

Mezey E, et al. "A randomized placebo controlled trial of vitamin E for alcoholic hepatitis." J Hepatol. 2004;40:40-46.

Andreone P, et al. "Vitamin E for chronic hepatitis B." Annal Int Med. January 15,1998;128(2):156-157.

von Herbay A, et al. "Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study." Free Radical Res. 1997;27:599-605.

Houglum K, et al. "A pilot study of the effects of d-à- tocopherol on hepatic stellate cell activation in chronic hepatitis C." Gastroenterol. 1997;113:1069-1073.

Meydani SN, et al. "Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial." JAMA, May7,1997;277(17):1380- 1386.

Barrow L. "Vitamin E deficiency in copper hepatotoxicity", J Ped Gastroenterol Nutr. 1989;9:264-265.

Zinc

Takagi H, et al. "Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C." J Viral Hepatitis. 2001;8:367-371.

Nagamine T, et al. "The possible role of zinc and metallothionein in the liver on the therapeutic effect of IFN-à to hepatitis C patients." Biol Trace Elem Res. 1997;58:65-76.

"Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis." Marchesini G, et al. Hepatol. May,1996;23(5):1084-1092.

Brodersen HP, et al. "Zinc supplementation and hepatitis B vaccination in chronic hemodialysis patients: a multicenter study." Nephrol Dialy Transplant. 1995;10:1780-1783.

Brewer GJ, et al. "Use of zinc acetate to treat copper toxicosis in dogs." J Vet Med Assoc. August15,1992;201(4):564-568.

Fakunle YM, et al. "Serum zinc levels in Saudi patients with chronic liver disease." Saudi Med J. July1991;12(4):347-348.

Selenium

Barbaro G. "Selenium deficiency and HIV-associated cardiomyopathy." J Royal Soc Med. January,2002;95:57.

Yu MW, et al. "Plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection." Am J Epidemiol. 1999;150(4):367-374.

McKenzie RC, et al. "Selenium: an essential element for immune function." Immunol Today. August,1998;19(8):342-345.

Look MP, et al. "Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection." Eur J Clin Nutr. 1997;51:266-272.

Yu SY, et al. "A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China." Biol Trace Elem Res. 1991;29:289-294.

Neve J. "Physiologic and nutritional importance of selenium." Experientia. 1991;47:187-193.

Yu SY, et al. "Chemoprevention trial of human hepatitis with selenium supplementation in China." Biol Trace Elem Res. 1989;20:15-22.

Korpela H, et al. "Decreased serum selenium in alcoholics as related to liver structure and function." Am J Clin Nutr. July,1985;42:147-151.

Supplement References

Glutathione

Boya P, et al. "Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C." J Hepatol. 1999;31:808-814.

Barbaro G, et al. "Hepatic glutathione deficiency in chronic hepatitis C: quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease." Am J Gastroenterol. 1996;91(12):2569-2573.

Loguercio C, et al. "Alteration of erythrocyte glutathione, cysteine and glutathione synthetase in alcoholic and non-alcoholic cirrhosis." Scand J Clin Lab Invest. 1992;52:207-213.

Thymus Glandular

Naylor PH, Mutchnick MG. "Thymus-derived peptides in the treatment of viral chronic hepatitis." Digest Dis. 1996;14:362-370.

Essential Fatty Acids

Cabre E, Gassull MA. "Polyunsaturated fatty acid deficiency in liver diseases: pathophysiological and clinical significance." Nutr. 1996;12:7/8.

S-Adenosyl-L Methionine (SAM)

Fiorelli G. "S-adenosylmethionine in the treatment of intrahepatic cholestasis of chronic liver disease: a field trial." Curr Ther Res. June,1999;60(6):335-348.

Marchesini G, et al. "Effect of S-adenosyl-L methionine administration on plasma levels of sulphur-containing plasma amino acids in patients with liver cirrhosis." Clin Nutr. 1992;11:303-308.

Frezza M, et al. "Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis: a double-blind placebo controlled study." Gastroenterol. 1990;99:211-215.

Friedal HA, et al. "S-adenosyl-L-methionine: a review of pharmacologic properties and therapeutic potential role in liver dysfunction and effective disorders in relation to its physiologic role in cell metabolism." Drugs. 1989;38(3);389-416.

Lipoic Acid

Berkson BM. "A triple antioxidant approach to the treatment of hepatitis C using alpha-lipoic acid (thioctic acid) silymarin, selenium, and other fundamental nutraceuticals." Clin Pract Altern Med. Spring,2000;1(1):27-33.

Berkson BM. "A conservative triple antioxidant approach to the treatment of hepatitis c: combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories." Med Klin. 1999;94(Suppl III):84-89.

Botanical References

Silybum

Flora K, et al. "Milk thistle (Silybum marianum) for the therapy of liver disease." Am J Gastroenterol. February,1998;93(2):139-143.

Fugh-Berman A. "Clinical trials of herbs." Prim Care. December,1997;24(4):889-903.

Garrido A, et al. "The flavonoid silybin ameliorates the protective effect of ethanol on acetaminophen hepatotoxicity." Res Comm Substances Abuse. 1989;10(3):193-196.

Glycyrrhiza

van Rossum TGJ, et al. "Glycyrrhizin-induced reduction of alt in european patients with chronic hepatitis C." Am J Gastroenterol. 2001;96(8):2432-2437.

Seeff LB, et al. "Complementary and alternative medicine in chronic liver disease." Hepatology. September,2001;34(3):595-603.

Van Rossum TGJ, et al. "Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial." J Gastroenterol Hepatol. 1999;14:1093-1099.

Yoshikawa M, et al. "Effects of glycyrrhizin on immune-mediated cytotoxicity." J Gastroenterol Hepatol. 1997;12:243-248.

Homeopathy References

Morrison R.Desktop Guide to Keynotes and Confirmatory Symptoms.Hahnemann Clinic Publishing; Albany, CA; 1993.

Murphy R.Homeopathic Medical Repertory.Hahnemann Academy of North America; Pagosa Springs, CO; 1993.

Phatak SR. A Concise Repertory of Homoeopathic Medicines. B. Jain Publishers Pvt. Ltd.; New Delhi, India; 1992.

Kruzel T. The Homeopathic Emergency Guide.North Atlantic Books; Berkeley, CA; 1992.

Kent JT. Repertory of the Homeopathic Materia Medica.B. Jain Publishers (P) LTD; New Delhi, India; 1991.

Boericke W. Materia Medica with Repertory, 9th Ed..Boericke & Tafel, Inc.; Santa Rosa, CA; 1927.

Other Treatment References

Avoid Excess Iron

Mandishona E, et al. "Dietary iron overload as a risk factor for hepatocellular carcinoma in black Africans." Hepatol. 1998;27:1563-1566.

Farinati F, et al. "Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive patients." J Hepatol. 1995;22:449-456.

Musumeci S, Leonardi S. "Could chelation therapy with deferoxamine enhance the percentage of responders to interferon therapy in chronic hepatitis C." ACTA Hematol. 1993;90:211-212.

Reizenstein P. "Iron, free radicals and cancer." Med Oncol Tumor Pharmacother. 1991;8(4):229-233.

Avoid Acetaminophen

Bonkovsky HL. "Acetaminophen hepatotoxicity, fasting, and ethanol." JAMA. July26,1995;276(4):301.

Wootton FT, Lee WM. "Acetaminophen hepatotoxicity in the alcoholic." Southern Med J. September1990;83(9):1047-1049.