Below are supplemental abstracts and references of research that support the conclusions on the treatment for Irritable Bowel Syndrome (IBS)

. Diet and Nutrition References


Food Allergies

Borok G. "Eczema and foods." SAMJ. February 2003;93(2):118-119.

Simren M, et al. "Food-related gastrointestinal symptoms in the irritable bowel syndrome." Digestion. 2001;63:108-115.

Locke GR, et al. "Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities." Am J Gastroenterol. 2000;95:157-165.

Niec AM, et al. "Are adverse food reactions linked to irritable bowel syndrome?" Am J Gastroenterol. November,1998;93(11):2184-2190.

Addolorato G, et al. "Anxiety and depression: a common feature of health care seeking patients with irritable bowel syndrome and food allergy." Hepatogastroenterol. 1998;45:1559-1564.

Vesa TH, et al. "Role of irritable bowel syndrome in subjective lactose intolerance." Am J Clin Nutr. 1998;67:710-715.

Bischoff SC, et al. "Food allergy in patients with gastrointestinal disease." Highlights Food Aller. 1996;32:130-142.

Borok G, et al. "Atopy: The incidence in chronic recurrent aaladies." XVI Europ Cong Allergol Clin Immunol. June 24-25,1995.

Smith MA, et al. "Food intolerance, atopy and irritable bowel syndrome." Lancet. November9,1985:1064.

Petitpierre M, et al. "Irritable bowel syndrome and hypersensitivity to food." Ann Allergy. June,1985;54:538-540.

Bentley SJ, et al. "Food hypersensitivity in irritable bowel syndrome." Lancet. August6,1983:295-297.

Birtwistle S. "Food intolerance and the irritable bowel." Lancet. September10,1983:634.

Jones VA, et al. "Food intolerance and the irritable bowel." Lancet. September10,1983:633-634.

Jones VA, et al. "Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome." Lancet. November20,1982:1115-1117.

Jewell DP, Truelove SC. "Circulating antibodies to cow's milk proteins in ulcerative colitis." Gut. 1972;13:796-801.


Sugar

Moukarzel AA, et al. "Irritable bowel syndrome and nonspecific diarrhea in infancy and childhood - relationship with juice carbohydrate malabsorption." Clin Pediatr. April,2002;41:145-150.

Miki K, et al. "The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease." J Pediatr. December,1998;133(6):750-754.

Russo A, et al. "The effect of acute hyperglycemia on small intestinal motility in normal subjects." Diabetologia. 1996(39):984-89.

Jarnerot G, et al. "Consumption of refined sugar by patients with Crohn's disease, ulcerative colitis, or irritable bowel syndrome." Scand J Gastroenterol. 1983;18:999-1002.


Refined Foods

Grimes DS, et al. "Refined carbohydrate, smooth muscle spasm and disease of the colon." Lancet. February21,1976(1):395-397.


Fiber

Parisi GC, et al. "High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (phgg)." Dig Dis Sci. August 2002;47(8):1697-1704.

Cann P, et al. "What is the benefit of coarse wheat bran in patients with irritable syndrome?" Gut. 1984(25):168-73.


Elemental Diet

Pimentel M, et al. "A 14-day elemental diet is highly effective in normalizing the lactulose breath test." Dig Dis Sci. January,2004;49(1):73-77.

King TS, et al. "Abnormal colonic fermentation in irritable bowel syndrome." Lancet. October10,1998;352:1187-1189.

Teahon, et al. "10 years experience with an elemental diet in the management of Crohn's disease." Gut. 1990:1133-37.


Vitamin and Mineral References


Vitamin A

Wright JP, et al. "Vitamin A therapy in patients with Crohn's disease." Gastroenterol. 1985;88:512.


Vitamin C, Vitamin E

Reif S, et al. "Pre-illness dietary factors in inflammatory bowel disease." Gut. 1997;40:754-760.

Marz RB. Medical Nutrition from Marz, 2 ed. Omni Press; Portland, OR; 1997:380.


Folate

Steger G, et al. "Folate absorption in Crohn's disease." Digestion. 1994;55:234-238.


Zinc

Matsui T. "Zinc deficiency in Crohn's disease." J Gastroenterol. 1998;33:924-925.

Goode HF. "Inflammatory bowel disease, free radicals and zinc." J Gastroenterol Hepatol. 1994;9:519-520.

McClain CJ, et al. "Zinc-deficiency-induced retinal dysfunction in Crohn's disease," Dig Dis Sci. January,1983;28(1):85-87.


Calcium

Valentine JF, Sninsky CA, "Prevention and treatment of osteoporosis in patients with inflammatory bowel disease." Am J Gastroenterol. 1999;94(4):878-883.

Steinbach G, et al. "Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects." Gastroenterol. 1994;106:1162-1167.


Magnesium

Galland L. "Magnesium and IBD." Magnesium. 1988;7:78-83.


Supplement References


Quercetin

Stephanini et al., "Efficacy of oral disodium cromoglycate in patients with IBS and positive skin tests to foods." Lancet. 1986;1:207-8.


EFA

Marz RB. Medical Nutrition from Marz, 2 ed. Omni-Press; Portland, OR; 1997:379-380.


Hydrochloric Acid

Marz RB. Medical Nutrition from Marz, 2 ed. Omni-Press; Portland, OR; 1997:381.


Fructooligosaccharides

Olesen M, Gudmand-Hoyer E. "Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome." Am J Clin Nutr. 2000;72:1570-1575.


Lactobacillus Acidophilus

Fedorak RN, Madsen KL. "Probiotics and prebiotics in gastrointestinal disorders." Curr Opin Gastroenterol. 2004;20:146-155.

Ouwehand AC, et al. "Probiotics: an overview of beneficial effects." Antonie Van Leeuwenhoek. 2002;82:279-289.

Niedzielin K, et al. "A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome." Eur J Gastroenterol Hepatol. 2001;13:1143-1147.

Marteau PR. "Probiotics in clinical conditions." Clin Rev Allergy Immunol. 2002;22:255-273.

Marteau PR, et al. "Protection from gastrointestinal diseases with the use of probiotics." J. Am J Clin Nutr. 2001;73(Suppl.):430S-436S.

O'Sullivan MA, O'Morain CA. "Bacterial supplementation in the irritable bowel syndrome. a randomised double-blind placebo-controlled crossover study." Digest Liver Dis. 2000;32:294-301.

Halpern GM, et al. "Treatment of irritable bowel syndrome with lacteol fort: A randomized, double-blind, cross-over trial." Am J Gastroenterol. 1996:91(8):1579-1585.


Fiber

Bennett WG, Cerda JJ. "Benefits of dietary fiber myth or medicine?" Postgraduate Med. 1996;February,99(2):153-172.


Botanical References


Althea

Lawrence Review of Natural Products: Althea officinalis. December,1991.

Delaveau I, et al. Planta Medica. 1980;40:49.


Geranium

Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy, Vol II. Eclectic Medical Publications; Sandy, OR;1993:347-8.


Echinacea

Balch JF, et al. Prescription for Nutritional Healing, 2nd ed. Avery Publication; NY, NY; 1997:148.

Lawrence Review of Natural Products: Echinacea. January 1990.

Stimpel, et al. "Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea." Inf Immunol. December,1984; 845-849.


Ulmus

Mabey R, Ed. The New Age Herbalist. Collier Books, Macmillan Publishing Co, NY, NT;1988:117.


Curcuma longa

Ammon, Wahl. "Pharmacology of Curcuma longa." Planta Medica. 1991;57:1-7.

Rafatullah S, et al. "Evaluation of tumeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats." J Ethnopharmacol. 1990;29:25-34.

Satoskar, et al. "Evaluation of anti-inflammatory property of Curcumin in patients with postoperative inflammation." Intr J Clin Pharmacol Ther Toxicol. 1986;12:65,1-2.

Chadra, Gupta. "Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa." Ind J Med Res. 1972;60:138-142.


Hydrastis

Felter HW. The Eclectic Materia Medica, Pharmacology and Therapeutics, Vol.I. Eclectic Medical Publications; Sandy, OR;1993:417-21.


Mentha piperita (Peppermint)

Pittler MH, Ernst E. "Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis." Am J Gastroenterol. July,1998;93(7):1131-1135.

Liu J-H, et al. "Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial." J Gastroenterol. 1997;32:765-768.

Beesley A, et al. "Influence of peppermint oil on absorptive and secretory processes in rat small intestine." Gut. 1996;39:214-219.

Hills JM, Aaronson PI. "The mechanism of action of peppermint oil on gastrointestinal smooth muscle: an analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig." Gastroenterol. July,1991;101(1):55-65.

Rogers J, et al. "Peppermint oil" Lancet. June9,1988:98-99.

Dew MJ, et al. "Peppermint oil for the irritable bowel syndrome: a multicentre trial." Br J Clin Pract. November/December,1984:394. 398.

Rees WDW, et al. "Treating irritable bowel syndrome with peppermint oil." Br Med J. October6,1979:835-836.


Althea officinalis, Geranium maculatum, Echinacea spp, Ulmus ruba, Curcuma longa, Hydrastis canadensis

Mitchell WA. Plant Medicine. Preparatory Manuscript; Seattle, WA; 2000.

Tilgner S. Herbal Medicine-From the Heart of the Earth. Wise Acres Press, Inc.; Creswell, OR; 1999.

Ogletree RL, Rischer RG. Physician's and Pharmacist's Guide to the Top 10 Scientifically Proven Natural Products. Natural Source Digest; 2nd Ed. Brandon, MS; 1997.

Chevallier A. The Encyclopedia of Medicinal Plants. DK Publishing; New York, NY; 1996.

Murray MT. The Healing Power of Herbs. 2nd Ed. Prima Publishing; Rocklin, CA; 1995.

Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy; Botanical Vol. II. Eclectic Medical Publications; Sandy, OR; 1994.

Felter HW. The Eclectic Materia Medica, Pharmacology and Therapeutics, Botanical Vol. 1. Eclectic Medical Publications; Sandy, OR; 1994.

Scalzo R. Naturopathic Handbook of Herbal Formulas. 3rd Ed. Kivaki Press; Durango, CO; 1994.

Ody P. The Complete Medicinal Herbal. Dorling Kindersley; New York, NY; 1993.

Stansbury JE. Botanical Medicines Acting on the Respiratory System. Preparatory Manuscript; Battleground, WA; 1992.

Stansbury JE. Pharmacognosy for the Herbal Practitioner. Preparatory Manuscript; Battleground, WA; 1992.

Thomas L. 10 Essential Herbs. Hohm Press; Prescott, AZ; 1992.

Weiss RF. Herbal Medicine. Beaconsfield Publishers LTD; Beaconsfield, England; 1991.

Hoffman D. The New Holistic Herbal. Element Inc; Rockport, MA; 1991.

Mabey R, et al. The New Age Herbalist. Collier Books, Macmillan Publishing Company; New York, NY; 1988. England;1988.

Tyler VE, et al. Pharmacognosy. 9th Ed. Lea & Febiger; Philadelphia, PA; 1988.

Wren RC. Potter's New Cyclopaedia of Botanical Drugs and Preparations. The C.W. Daniel Company Limited; Essex; 1988

Carr A, et al. Rodale's Illustrated Encyclopedia of Herbs. Rodale Press; Emmaus, PA; 1987.

Mowrey DB. The Scientific Validation of Herbal Medicine. Keats Publishing, Inc.; New Canaan, CT; 1986.

Beyer P. The Master Book of Herbalism. Phoenix Publishing; Custer, WA; 1984.

Goodenough J. Dr. Goodenough's Home Cures & Herbal Remedies. Avenel Books; New York, NY; 1982.

Millspaugh CF. American Medicinal Plants. Dover Publications, Inc.; New York, NY; 1974.

Grieve M. A Modern Herbal. Vol. I & II; Dover Publications, Inc.; New York, NY; 1971.


Homeopathy References


Morrison R.Desktop Guide to Keynotes and Confirmatory Symptoms.Hahnemann Clinic Publishing; Albany, CA; 1993.

Murphy R.Homeopathic Medical Repertory.Hahnemann Academy of North America; Pagosa Springs, CO; 1993.

Phatak SR. A Concise Repertory of Homoeopathic Medicines. B. Jain Publishers Pvt. Ltd.; New Delhi, India; 1992.

Kruzel T. The Homeopathic Emergency Guide.North Atlantic Books; Berkeley, CA; 1992.

Kent JT. Repertory of the Homeopathic Materia Medica.B. Jain Publishers (P) LTD; New Delhi, India; 1991.

Boericke W. Materia Medica with Repertory, 9th Ed..Boericke & Tafel, Inc.; Santa Rosa, CA; 1927.


Morrison R.Desktop Guide to Keynotes and Confirmatory Symptoms.Hahnemann Clinic Publishing; Albany, CA; 1993.

Murphy R.Homeopathic Medical Repertory.Hahnemann Academy of North America; Pagosa Springs, CO; 1993.

Phatak SR. A Concise Repertory of Homoeopathic Medicines. B. Jain Publishers Pvt. Ltd.; New Delhi, India; 1992.

Kruzel T. The Homeopathic Emergency Guide.North Atlantic Books; Berkeley, CA; 1992.

Kent JT. Repertory of the Homeopathic Materia Medica.B. Jain Publishers (P) LTD; New Delhi, India; 1991.

Boericke W. Materia Medica with Repertory, 9th Ed..Boericke & Tafel, Inc.; Santa Rosa, CA; 1927.


Other Treatment References


Lactobacillus Acidophilus Enema

Walker WA, Duffy LC, "Diet and bacterial colonization: role of probiotics and prebiotics." J Nutr Biochem. December,1998;9(12):668-675.

Bennet, et al., "Treatment of UC by implantation of normal colonic flora." Lancet. 1989;Jan 21.


Relaxation

Blanchard EB, et al. "Relaxation training as a treatment for irritable bowel syndrome." Biofeedback Self-Regulation. 1993;18(3):125-131.


Stress

Dancey CP, et al. "The relationship between daily stress and symptoms of irritable bowel: a time-series approach." J Psychosom Res. 1998;44(5):537-545.

Whorwell PJ, et al. "Physiologic effects of emotion: assessment via hypothesis." Lancet. July11,1992;340:69-72.

Shaw G, et al. "Stress management for irritable bowel syndrome: a controlled trial." Digestion. 1991;50:36-42.


Hypnotherapy

Houghton LA, et al. "Symptomatology, quality of life and economic features of irritable bowel syndrome - the effect of hypnotherapy." Aliment Pharmacol Ther. February,1996;10(1):91-95.


Smoking

Bustamante M, et al. "Relationship between smoking and colonic involvement in inflammatory bowel disease." Rev Esp Enferm Dig. 1998;90(12):837-840.

Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).