Coenzyme Q10 (Ubiquinone)

Description:

Coenzyme Q10 is a cofactor for cellular respiration (electron transport chain) and is essential for the health of all organs and tissues. All energy-dependent processes of the body require Co Q10.

Clinical Indications:

• Aging prevention
• AIDS
• Allergies
• Alzheimer's disease
• Asthma
• Atherosclerosis
• Chronic fatigue syndrome
• Congestive heart failure
• Diabetes mellitus
• Fertility/Infertility
• Hypertension
• Obesity
• Parkinson's Disease
• Peptic ulcer
• Adriamycin cardiotoxicity
• Angina pectoris
• Beta-blocker toxicity
• Cancer
• Cardiomyopathy
• Cardiotoxicity of psychotropic drugs - including phenothiazines, tricyclic antidepressants
• Enhance aerobic capacity and muscle performance
• Hyperthyroid heart failure
• Immune system - tissues and cells involved with immune function are highly energy-dependent
• Mitral valve prolapse
• Muscular dystrophy
• Periodontal disease

Dosage:

• 20 - 150 mg. per day in divided doses
• Adriamycin therapy: 100 mg. per day in divided doses beginning 3 - 5 days prior to treatment may help prevent cardiotoxicity

Drug/Nutrient Interaction:

• Adriamycin, lovastatin, and other HMG CoA-reductase inhibitors may produce a deficiency of Co Q10
• Coenzyme Q10 can be antagonized by tricyclic antidepressants and beta blockers
• Coenzyme Q10, used with doxorubicin, lessens the cardiotoxicity and can double the anti-tumor effects of doxorubicin
• Dymelor can cause a deficiency of Co Q10 which may lead to cardiac symptoms
• Glyburide can cause a deficiency of Co Q10 and inhibits NADH oxidase, a coenzyme Q10 enzyme
• Phenoformin can cause a deficiency of Co Q10
• Tolazamide can cause a deficiency of Co Q10 with prolonged use

Adverse Reactions and Toxicity:

• Generally well tolerated
• Restrict during pregnancy and lactation because no studies have been done

Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).